In this clip, Dr. Eric Verdin, President and CEO of the Buck Institute for Research on Aging, breaks down the science behind NAD⁺—a vital coenzyme required by our mitochondria to produce cellular energy. NAD⁺ levels rise during fasting and decline naturally with age, affecting critical enzymes like sirtuins and PARPs that are essential for DNA repair and healthy aging.
Dr. Verdin explores leading hypotheses on why NAD⁺ declines over time: either it’s being depleted to repair accumulated DNA damage, or the body’s ability to recycle it simply deteriorates with age. NAD⁺ supplementation has emerged as a potential strategy to restore cellular energy and counteract some aging-related symptoms, though the science is still evolving
Why This Matters:
As we age, energy production and cellular repair processes slow down—impacting everything from brain function to physical endurance. Replenishing NAD⁺ levels is one of several emerging strategies to optimize mitochondrial health and slow biological aging.
At Clay Health & Care, we explore these advances with clinical rigor, offering cutting-edge therapies like NAD⁺ IVs and supplements as part of personalized health optimization programs.