In this episode, Dr. Rhonda Patrick breaks down the essential role of NAD⁺ in cellular energy and aging. She explains how everyday stressors and natural aging deplete NAD⁺ levels, leading to mitochondrial dysfunction and DNA damage. The discussion explores whether NAD⁺ precursors like NR and NMN—known to increase NAD⁺ in animals—can do the same in humans. While early data is promising, questions remain about their long-term safety and effectiveness in people.
Why This Matters:
NAD⁺ is a linchpin in the body’s energy systems, playing a critical role in mitochondrial function, DNA repair, and overall metabolic health. As NAD⁺ levels drop with age, the body becomes more vulnerable to chronic disease and cellular decline. Interventions like NR and NMN may offer a proactive way to support energy production and delay age-related deterioration—but they need to be applied with evidence, caution, and expert guidance.
At Clay Health & Care, we track these innovations closely to help people stay ahead of aging by understanding their biomarkers, using targeted therapies, and making informed decisions about their long-term healthspan.