Building muscle through resistance training is not just about aesthetics or athleticism—it’s about extending your lifespan and improving the quality of your years. As experts like Dr. Gabrielle Lyon and Dr. Casey Means emphasize, skeletal muscle plays a foundational role in metabolic health, disease prevention, and maintaining independence as we age.
Let’s explore how and why muscle is one of the most underutilized yet powerful tools in your health arsenal.
Muscle: The Organ of Longevity
Skeletal muscle is the largest organ in the body and a metabolic powerhouse. Dr. Gabrielle Lyon, founder of Muscle-Centric Medicine®, refers to it as the “organ of longevity”—and for good reason.
Here’s what muscle does behind the scenes:
- Burns calories at rest, boosting your metabolism and aiding fat loss.
- Improves insulin sensitivity, helping regulate blood sugar and lowering the risk of type 2 diabetes.
- Supports weight management by increasing your resting metabolic rate.
🔬 Science Spotlight: A 2021 study in Frontiers in Endocrinology found resistance training improves insulin sensitivity, a major protective factor against metabolic disease.
Muscle Mass = Life Span
Higher levels of muscle mass are strongly associated with lower all-cause mortality rates. In other words: people with more muscle live longer—and better.
As we age, we naturally lose muscle through a process called sarcopenia, which leads to frailty, reduced mobility, and higher risk of injury. Dr. Lyon introduces the idea of “muscle span”—the length of time you retain enough muscle strength to live independently and actively.
Building and maintaining muscle extends your muscle span, enabling you to age with strength, grace, and freedom.
📚 Frontiers in Physiology found that individuals with higher muscle mass had significantly lower mortality rates, regardless of body fat percentage.

Clay’s Health Optimization Assessment tracks muscle mass and muscle span—two of the most important indicators of long-term strength, resilience, and longevity.
Muscle Is a Metabolic Engine
Dr. Casey Means, Stanford-trained physician and expert in metabolic health, reinforces muscle’s importance in optimizing body composition and vitality. In her conversations with Dr. Lyon, she underlines the synergy between diet, movement, and muscle health as keys to improving long-term metabolic outcomes.
Weekly muscle-building supports:
- Resting metabolic rate (so you burn more calories 24/7)
- Blood sugar stability (by acting as a glucose sink)
- Physical resilience (better balance, strength, and fall prevention)
- Emotional strength (more confidence, energy, and grit)
Protein: The Daily Lever You Can Pull
Muscle growth doesn’t happen without intentional inputs. With age comes anabolic resistance, meaning your body responds less efficiently to strength training and protein intake
Dr. Lyon’s recommendation:
- 1.6–2.2 grams of protein per kilogram of body weight per day
- Prioritize high-quality protein sources with every meal
- Pair with consistent resistance training to counteract aging’s effects
“Only 24% of people meet exercise recommendations. But 100% of us eat every day. That makes protein a daily opportunity to build muscle.”
—Dr. Gabrielle Lyon
Five Reasons Muscle Must Be a Weekly Focus
- Fat Loss & Weight Management
Muscle increases caloric burn, even at rest. - Metabolic Protection
Resistance training improves insulin sensitivity and blood sugar control. - Injury & Fall Prevention
Strong muscles support balance, coordination, and bone health. - Chronic Disease Shield
More muscle = reduced risk for obesity, cardiovascular disease, and diabetes. - Confidence & Motivation
Strength training improves energy, mood, and psychological resilience.
It’s Never Too Late to Start
Whether you’re 25 or 75, resistance training can transform your health trajectory. Research shows that even older adults can gain muscle and strength with consistent, properly dosed training.
Getting started doesn’t require a gym or hours a day:
- Bodyweight exercises
- Dumbbells or resistance bands
- Functional movements 2–3x/week
- Fueling with sufficient protein
Every rep is an investment in your future. Stay consistent. Stay strong.
Final Word: Build Now, Thrive Later
At Clay, we believe muscle is a vital marker of health. It’s not just about looking fit—it’s about building a resilient body that supports you for life. From boosting your energy today to extending your independence tomorrow, muscle matters.
Make it part of your weekly non-negotiables. Your future self will thank you.
Sources
- Lyon, G. (2023). Forever Strong: A New, Science-Based Strategy for Aging Well. https://drgabriellelyon.com/
- “Role of Dietary Protein and Muscular Fitness on Longevity and Aging.” PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC5772850/
- “Muscle Mass Index as a Predictor of Longevity in Older-Adults.” PMC. https://pmc.ncbi.nlm.nih.gov/articles/PMC4035379/
- Huberman Lab Podcast with Dr. Gabrielle Lyon. https://www.hubermanlab.com/episode/dr-gabrielle-lyon-how-to-exercise-eat-for-optimal-health-longevity
- Levels Health Podcast with Dr. Gabrielle Lyon and Dr. Casey Means. https://www.levelshealth.com/podcasts/234-why-your-workout-isnt-working-for-you-and-what-to-do-instead-for-improved-metabolic-health-and-body-composition-dr-gabrielle-lyon-dr-casey-means
- Muscle increases resting metabolic rate, aiding fat loss (Frontiers in Endocrinology, 2021)
- Muscle improves insulin sensitivity, reducing diabetes risk (Frontiers in Endocrinology, 2021)
- Higher muscle mass linked to lower mortality (Frontiers in Physiology)
- Muscle reduces fall risk and enhances mobility (PMC: Muscle Mass Index, 2014)
- Strength training boosts confidence and energy (Journal of Strength and Conditioning Research, 2020)